diff --git a/package.json b/package.json
index fa01703787..a3150d8551 100644
--- a/package.json
+++ b/package.json
@@ -124,6 +124,7 @@
     "intersection-observer": "^0.12.2",
     "intl-messageformat": "10.5.8",
     "intl-pluralrules": "^2.0.0",
+    "isomorphic-dompurify": "^2.3.0",
     "leaflet": "^1.8.0",
     "lexical": "^0.12.4",
     "line-awesome": "^1.3.0",
diff --git a/src/features/landing-timeline/components/site-banner.tsx b/src/features/landing-timeline/components/site-banner.tsx
index 194faecc64..ffbdafe354 100644
--- a/src/features/landing-timeline/components/site-banner.tsx
+++ b/src/features/landing-timeline/components/site-banner.tsx
@@ -1,3 +1,4 @@
+import DOMPurify from 'isomorphic-dompurify';
 import React from 'react';
 
 import Markup from 'soapbox/components/markup';
@@ -9,7 +10,7 @@ import { LogoText } from './logo-text';
 
 const SiteBanner: React.FC = () => {
   const instance = useInstance();
-  const description = instance.description;
+  const description = DOMPurify.sanitize(instance.description);
 
   return (
     <Stack space={3}>
diff --git a/src/normalizers/status-edit.ts b/src/normalizers/status-edit.ts
index f569ecce3f..26619c1747 100644
--- a/src/normalizers/status-edit.ts
+++ b/src/normalizers/status-edit.ts
@@ -8,6 +8,7 @@ import {
   Record as ImmutableRecord,
   fromJS,
 } from 'immutable';
+import DOMPurify from 'isomorphic-dompurify';
 
 import emojify from 'soapbox/features/emoji';
 import { normalizeAttachment } from 'soapbox/normalizers/attachment';
@@ -60,8 +61,8 @@ const normalizeStatusPoll = (statusEdit: ImmutableMap<string, any>) => {
 
 const normalizeContent = (statusEdit: ImmutableMap<string, any>) => {
   const emojiMap   = makeEmojiMap(statusEdit.get('emojis'));
-  const contentHtml = stripCompatibilityFeatures(emojify(statusEdit.get('content'), emojiMap));
-  const spoilerHtml = emojify(escapeTextContentForBrowser(statusEdit.get('spoiler_text')), emojiMap);
+  const contentHtml = DOMPurify.sanitize(stripCompatibilityFeatures(emojify(statusEdit.get('content'), emojiMap)), { ADD_ATTR: ['target'] });
+  const spoilerHtml = DOMPurify.sanitize(emojify(escapeTextContentForBrowser(statusEdit.get('spoiler_text')), emojiMap), { ADD_ATTR: ['target'] });
 
   return statusEdit
     .set('contentHtml', contentHtml)
diff --git a/src/reducers/statuses.ts b/src/reducers/statuses.ts
index 0b94d228a3..b857ba5403 100644
--- a/src/reducers/statuses.ts
+++ b/src/reducers/statuses.ts
@@ -1,5 +1,6 @@
 import escapeTextContentForBrowser from 'escape-html';
 import { Map as ImmutableMap, List as ImmutableList } from 'immutable';
+import DOMPurify from 'isomorphic-dompurify';
 
 import emojify from 'soapbox/features/emoji';
 import { normalizeStatus } from 'soapbox/normalizers';
@@ -119,8 +120,8 @@ export const calculateStatus = (
 
     return status.merge({
       search_index: domParser.parseFromString(searchContent, 'text/html').documentElement.textContent || '',
-      contentHtml: stripCompatibilityFeatures(emojify(status.content, emojiMap)),
-      spoilerHtml: emojify(escapeTextContentForBrowser(spoilerText), emojiMap),
+      contentHtml: DOMPurify.sanitize(stripCompatibilityFeatures(emojify(status.content, emojiMap)), { USE_PROFILES: { html: true } }),
+      spoilerHtml: DOMPurify.sanitize(emojify(escapeTextContentForBrowser(spoilerText), emojiMap), { USE_PROFILES: { html: true } }),
       hidden: expandSpoilers ? false : spoilerText.length > 0 || status.sensitive,
     });
   }
diff --git a/src/schemas/account.ts b/src/schemas/account.ts
index a0a718db7a..b419b13cf2 100644
--- a/src/schemas/account.ts
+++ b/src/schemas/account.ts
@@ -1,4 +1,5 @@
 import escapeTextContentForBrowser from 'escape-html';
+import DOMPurify from 'isomorphic-dompurify';
 import z from 'zod';
 
 import emojify from 'soapbox/features/emoji';
@@ -115,7 +116,7 @@ const transformAccount = <T extends TransformableAccount>({ pleroma, other_setti
 
   const newFields = fields.map((field) => ({
     ...field,
-    name_emojified: emojify(escapeTextContentForBrowser(field.name), customEmojiMap),
+    name_emojified: DOMPurify.sanitize(emojify(escapeTextContentForBrowser(field.name), customEmojiMap), { USE_PROFILES: { html: true } }),
     value_emojified: emojify(field.value, customEmojiMap),
     value_plain: unescapeHTML(field.value),
   }));
@@ -133,7 +134,7 @@ const transformAccount = <T extends TransformableAccount>({ pleroma, other_setti
     avatar_static: account.avatar_static || account.avatar,
     discoverable: account.discoverable || account.source?.pleroma?.discoverable || false,
     display_name: displayName,
-    display_name_html: emojify(escapeTextContentForBrowser(displayName), customEmojiMap),
+    display_name_html: DOMPurify.sanitize(emojify(escapeTextContentForBrowser(displayName), customEmojiMap), { USE_PROFILES: { html: true } }),
     domain,
     fields: newFields,
     fqn: account.fqn || (account.acct.includes('@') ? account.acct : `${account.acct}@${domain}`),
@@ -141,7 +142,7 @@ const transformAccount = <T extends TransformableAccount>({ pleroma, other_setti
     moderator: pleroma?.is_moderator || false,
     local: pleroma?.is_local !== undefined ? pleroma.is_local : account.acct.split('@')[1] === undefined,
     location: account.location || pleroma?.location || other_settings?.location || '',
-    note_emojified: emojify(account.note, customEmojiMap),
+    note_emojified: DOMPurify.sanitize(emojify(account.note, customEmojiMap), { USE_PROFILES: { html: true } }),
     pleroma: (() => {
       if (!pleroma) return undefined;
       const { relationship, ...rest } = pleroma;
diff --git a/src/schemas/poll.ts b/src/schemas/poll.ts
index 65ead6e149..1a60af410a 100644
--- a/src/schemas/poll.ts
+++ b/src/schemas/poll.ts
@@ -1,4 +1,5 @@
 import escapeTextContentForBrowser from 'escape-html';
+import DOMPurify from 'isomorphic-dompurify';
 import { z } from 'zod';
 
 import emojify from 'soapbox/features/emoji';
@@ -30,7 +31,7 @@ const pollSchema = z.object({
 
   const emojifiedOptions = poll.options.map((option) => ({
     ...option,
-    title_emojified: emojify(escapeTextContentForBrowser(option.title), emojiMap),
+    title_emojified: DOMPurify.sanitize(emojify(escapeTextContentForBrowser(option.title), emojiMap), { ALLOWED_TAGS: [] }),
   }));
 
   // If the user has votes, they have certainly voted.
diff --git a/yarn.lock b/yarn.lock
index 77b106535e..1235e8045e 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -2375,6 +2375,13 @@
     "@types/node" "*"
     "@types/responselike" "^1.0.0"
 
+"@types/dompurify@^3.0.5":
+  version "3.0.5"
+  resolved "https://registry.yarnpkg.com/@types/dompurify/-/dompurify-3.0.5.tgz#02069a2fcb89a163bacf1a788f73cb415dd75cb7"
+  integrity sha512-1Wg0g3BtQF7sSb27fJQAKck1HECM6zV1EB66j8JH9i3LCjYabJa0FSdiSgsD5K/RbrsR0SiraKacLB+T8ZVYAg==
+  dependencies:
+    "@types/trusted-types" "*"
+
 "@types/escape-html@^1.0.1":
   version "1.0.1"
   resolved "https://registry.yarnpkg.com/@types/escape-html/-/escape-html-1.0.1.tgz#b19b4646915f0ae2c306bf984dc0a59c5cfc97ba"
@@ -2612,6 +2619,11 @@
   resolved "https://registry.yarnpkg.com/@types/semver/-/semver-7.5.2.tgz#31f6eec1ed7ec23f4f05608d3a2d381df041f564"
   integrity sha512-7aqorHYgdNO4DM36stTiGO3DvKoex9TQRwsJU6vMaFGyqpBA1MNZkz+PG3gaNUPpTAOYhT1WR7M1JyA3fbS9Cw==
 
+"@types/trusted-types@*":
+  version "2.0.7"
+  resolved "https://registry.yarnpkg.com/@types/trusted-types/-/trusted-types-2.0.7.tgz#baccb07a970b91707df3a3e8ba6896c57ead2d11"
+  integrity sha512-ScaPdn1dQczgbl0QFTeTOmVHFULt394XJgOQNoyVhZ6r2vLnMLJfBPd53SB52T/3G36VI1/g2MZaX0cwDuXsfw==
+
 "@types/trusted-types@^2.0.2":
   version "2.0.4"
   resolved "https://registry.yarnpkg.com/@types/trusted-types/-/trusted-types-2.0.4.tgz#2b38784cd16957d3782e8e2b31c03bc1d13b4d65"
@@ -3885,6 +3897,13 @@ cssstyle@^3.0.0:
   dependencies:
     rrweb-cssom "^0.6.0"
 
+cssstyle@^4.0.1:
+  version "4.0.1"
+  resolved "https://registry.yarnpkg.com/cssstyle/-/cssstyle-4.0.1.tgz#ef29c598a1e90125c870525490ea4f354db0660a"
+  integrity sha512-8ZYiJ3A/3OkDd093CBT/0UKDWry7ak4BdPTFP2+QEP7cmhouyq/Up709ASSj2cK02BbZiMgk7kYjZNS4QP5qrQ==
+  dependencies:
+    rrweb-cssom "^0.6.0"
+
 csstype@^3.0.2:
   version "3.0.9"
   resolved "https://registry.yarnpkg.com/csstype/-/csstype-3.0.9.tgz#6410af31b26bd0520933d02cbc64fce9ce3fbf0b"
@@ -4101,6 +4120,11 @@ domhandler@^4.2.0, domhandler@^4.3.1:
   dependencies:
     domelementtype "^2.2.0"
 
+dompurify@^3.0.8:
+  version "3.0.8"
+  resolved "https://registry.yarnpkg.com/dompurify/-/dompurify-3.0.8.tgz#e0021ab1b09184bc8af7e35c7dd9063f43a8a437"
+  integrity sha512-b7uwreMYL2eZhrSCRC4ahLTeZcPZxSmYfmcQGXGkXiZSNW1X85v+SDM5KsWcpivIiUBH47Ji7NtyUdpLeF5JZQ==
+
 domutils@^2.8.0:
   version "2.8.0"
   resolved "https://registry.yarnpkg.com/domutils/-/domutils-2.8.0.tgz#4437def5db6e2d1f5d6ee859bd95ca7d02048135"
@@ -5699,6 +5723,15 @@ isexe@^2.0.0:
   resolved "https://registry.yarnpkg.com/isexe/-/isexe-2.0.0.tgz#e8fbf374dc556ff8947a10dcb0572d633f2cfa10"
   integrity sha1-6PvzdNxVb/iUehDcsFctYz8s+hA=
 
+isomorphic-dompurify@^2.3.0:
+  version "2.3.0"
+  resolved "https://registry.yarnpkg.com/isomorphic-dompurify/-/isomorphic-dompurify-2.3.0.tgz#bc48fbdf52f84cf7e0a63a5e8ec89052e7dbc3c5"
+  integrity sha512-FCoKY4/mW/jnn/+VgE7wXGC2D/RXzVCAmGYuGWEuZXtyWnwmE2100caciIv+RbHk90q9LA0OW5IBn2f+ywHtww==
+  dependencies:
+    "@types/dompurify" "^3.0.5"
+    dompurify "^3.0.8"
+    jsdom "^24.0.0"
+
 iterator.prototype@^1.1.2:
   version "1.1.2"
   resolved "https://registry.yarnpkg.com/iterator.prototype/-/iterator.prototype-1.1.2.tgz#5e29c8924f01916cb9335f1ff80619dcff22b0c0"
@@ -5792,6 +5825,33 @@ jsdom@^23.0.0:
     ws "^8.14.2"
     xml-name-validator "^5.0.0"
 
+jsdom@^24.0.0:
+  version "24.0.0"
+  resolved "https://registry.yarnpkg.com/jsdom/-/jsdom-24.0.0.tgz#e2dc04e4c79da368481659818ee2b0cd7c39007c"
+  integrity sha512-UDS2NayCvmXSXVP6mpTj+73JnNQadZlr9N68189xib2tx5Mls7swlTNao26IoHv46BZJFvXygyRtyXd1feAk1A==
+  dependencies:
+    cssstyle "^4.0.1"
+    data-urls "^5.0.0"
+    decimal.js "^10.4.3"
+    form-data "^4.0.0"
+    html-encoding-sniffer "^4.0.0"
+    http-proxy-agent "^7.0.0"
+    https-proxy-agent "^7.0.2"
+    is-potential-custom-element-name "^1.0.1"
+    nwsapi "^2.2.7"
+    parse5 "^7.1.2"
+    rrweb-cssom "^0.6.0"
+    saxes "^6.0.0"
+    symbol-tree "^3.2.4"
+    tough-cookie "^4.1.3"
+    w3c-xmlserializer "^5.0.0"
+    webidl-conversions "^7.0.0"
+    whatwg-encoding "^3.1.1"
+    whatwg-mimetype "^4.0.0"
+    whatwg-url "^14.0.0"
+    ws "^8.16.0"
+    xml-name-validator "^5.0.0"
+
 jsesc@^2.5.1:
   version "2.5.2"
   resolved "https://registry.yarnpkg.com/jsesc/-/jsesc-2.5.2.tgz#80564d2e483dacf6e8ef209650a67df3f0c283a4"
@@ -9483,6 +9543,11 @@ ws@^8.14.2:
   resolved "https://registry.yarnpkg.com/ws/-/ws-8.14.2.tgz#6c249a806eb2db7a20d26d51e7709eab7b2e6c7f"
   integrity sha512-wEBG1ftX4jcglPxgFCMJmZ2PLtSbJ2Peg6TmpJFTbe9GZYOQCDPdMYu/Tm0/bGZkw8paZnJY45J4K2PZrLYq8g==
 
+ws@^8.16.0:
+  version "8.16.0"
+  resolved "https://registry.yarnpkg.com/ws/-/ws-8.16.0.tgz#d1cd774f36fbc07165066a60e40323eab6446fd4"
+  integrity sha512-HS0c//TP7Ina87TfiPUz1rQzMhHrl/SG2guqRcTOIUYD2q8uhUdNHZYJUaQ8aTGPzCh+c6oawMKW35nFl1dxyQ==
+
 xcase@^2.0.1:
   version "2.0.1"
   resolved "https://registry.yarnpkg.com/xcase/-/xcase-2.0.1.tgz#c7fa72caa0f440db78fd5673432038ac984450b9"